|Portrayed by:||Emily Beecham|
|Appearance(s):||28 Weeks Later|
|Cause of death:||Skull bludgeoned by Don Harris with a crowbar|
When the Original Outbreak of the Rage Virus occurred, Sam and Karen were taken in by Geoff and Sally and holed up in Geoff and Sally's barricaded cottage with them. At some point, Sam left the cottage and apparently abandoned Karen, leaving her catatonic and in denial that her boyfriend had deserted her.
Five days after Sam abandoned the group, when the survivors were preparing to have a dinner of pasta, Karen saved hers for Sam out of denial that Sam was likely either dead or infected and wouldn't come back.
The survivors then let in a young Boy from Sandford, and moments later the cottage was attacked by a horde of Infected. An infected woman grabbed Karen's arm through the kitchen window and bit her on the wrist, exposing her. Jacob then pulled Karen away, but she promptly became infected and began attacking him on the floor, until Donald Harris bludgeoned and killed her with a crowbar.
Karen was left catatonic and helpless after Sam abandoned her, and was also left in a state of denial that Sam was either dead or infected and was not going to come back for her.